HFXII 1212 Human
Factor XII (Hageman Factor)
Purified from fresh frozen
human plasma. Human Factor XII is part of the contact activation system.
Human Factor XII is a single chain glycoprotein with a molecular weight
of about 80,000. Once activated, principally from the action of kallikrein,
Factor XII is converted into an active serine protease (Factor α-Xlla)
that functions in the in vivo
initiation of blood coagulation, fibrinolysis, and kinin formation.
Human Factor XII has been purified by ion exchange chromatography.
Protein purity is determined by SDS-PAGE and activity is determined via
clotting assay.
Buffer composition = 4
mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
*Extinction Coefficient (1%) =14.1
Molecular Weight = 80,000 daltons
Human Factor XII Sample Certificate of Analysis