HFXIII 1313 Human
Factor XIII (Fibrin Stabilizing Factor)
Human Factor XIII is a
tetramer composed of two pairs of chains held together by noncovalent
bonds. After activation of the zymogen via Thrombin to its active
enzyme form, Factor XIIIa is responsible for catalyzing the formation
of covalent bridges between fibrin units to increase the elasticity
of the clot network. The resulting cross-linked fibrin is very insoluble
and resistant to lysis.
Buffer composition =50 mM Tris-HCl/0.1 M NaCl/1 mM
EDTA/10u/mL aprotinin/20% glycerol/pH 7.5
*Extinction Coefficient (1%)=13.8
Molecular Weight = 320,000 daltons
Human Factor XIII Sample Certificate of Analysis