HPC 1001
Human Protein C
Purified from
fresh frozen human plasma using a combination of salt precipitations
and column chromatography. The protein purity is determined by SDS-PAGE
and shows total reduction upon incubation with 2-mercaptoethanol.
Protein C is activated to the serine protease, Activated Protein C
(APC), by a-thrombin or the complex of a-thrombin/thrombomodulin and is
a potent anticoagulant through the selective inactivation of Factors Va
and VIIIa.
Buffer composition = 20
mM Tris-HCl/0.1 M NaCl/1 mM Benzamidine/pH 7.4
*Extinction Coefficient (1%) = 14.5
Molecular Weight = 62,000 daltons
Also available: des-Gla-Human Protein C
Human Protein C Sample Certificate of Analysis