HK 1300 Single Chain High Molecular Wt. Kininogen
(Fitzgerald Factor)
High Molecular Weight Kininogen
(HK) is a nonenzymatic cofactor of the contact activation system.
HK is thought to have two functions in the contact activation system.
First, HK links prekallikrein to a negatively charged surface thereby
allowing activation to kallikrein by surface bound Factor α-Xlla.
HK also forms a complex with Factor XI and accelerates its activation
to XIa by α-Xlla. Also HK serves as a source of Bradykinin, a potent
Vasoactive peptide important in hypotension studies. The protein purity is determined by SDS-PAGE
Buffer composition = 4 mM Sodium Acetate-HCl/0.15
M NaCl/pH 5.3
*Extinction Coefficient (1%) = 7.01
Molecular Weight = 120,000 daltons
Single Chain High Molecular Wt. Kininogen Sample Certificate of Analysis