APC Human
Activated Protein C
Activated Protein C (APC) is a serine protease derived from the two chain vitamin
K dependent zymogen, Protein C. APC inhibits blood coagulation through
the selective inactivation of the cofactors Va and VIIIa. APC is
prepared from protein C by activation with purified thrombin. This
thrombin is removed after activation by ion exchange chromatography.
Activated Protein C purity is determined by SDS-PAGE and shows
complete reduction upon incubation with 2-mercaptoethanol.
Buffer composition = 20 mM Tris-HCl/0.1 M NaCl/ pH
7.4
*Extinction Coefficient (1%) = 14.5
Molecular Weight = 56,000 daltons
Also available: des-Gla-Human Activated Protein C
Human Activated Protein C Sample Certificate of Analysis