HFXIIa 1212a
Human Factor αXIIa
(Activated Hageman Factor)
Human Factor α-XIIa
is a serine protease responsible for the activation of Factor XI to
XIa in the contact activation system. Human Factor XII and prekallikrein
are thought to be involved in a reciprocal activation mechanism in
which Factor XIIa activates prekallikrein to kallikrein, which in
turn converts Factor XII to XIIa. Factor XIIa activates Factor XI
to XIa thereby triggering the Contact Factor cascade. ERL offers Factor
α-XIIa which is activated by the autoactivation process with Dextran Sulfate
and re-purified to remove the activator. The protein purity is
determined by SDS-PAGE and activity is determined via clotting assay.
Buffer composition
= 4 mM Sodium Acetate-HCl/0.15 M NaCl/pH 5.3
*Extinction Coefficient (1%) = 14.1
Molecular Weight = 80,000 daltons
Also available: Human Factor XIIa beta
Human Factor XIIa Sample Certificate of Analysis