HAPO-H Apolipoprotein-H(β2GP-1)
Apolipoprotein-H, also known as β2Glycoprotein-1 (β2GP-1) is a
plasma glycoprotein that circulates at a concentration of 200 µg/mL
(4mM). β2GP-1 has been identified as a constituent of chylomicrons,
very low density lipoproteins and high density lipoproteins in Human
plasma. It has also been demonstrated to bind phospholipids, heparin
and platelets where it can modulate the activity of adenylate (19%).
Although the precise function(s) are as yet unknown, β2GP-1 has been
shown to interfere with blood coagulation by competitively binding to
phospholipids exposed during cell activation or damage. Recent evidence
also implicates β2GP-1 as a cofactor recognized by some
anti-phospholipid antibodies present in autoimmune disorders such as
systemic lupus erythematosus(SLE).
Buffer composition = 20
mM Tris-HCl/0.3 M NaCl /pH 7.3
Extinction Coefficient (1%) = 9.4
Molecular Weight = 48,000 daltons
Apolipoprotein-H Sample Certificate of Analysis